After oral administration, sumatriptan is rapidly absorbed, 70% of the maximum plasma concentration is reached after 45 minutes. After receiving 100 mg of the maximum concentration in plasma is on average 54 ng / ml. Bioavailability is 14% as a result of the intensive first-pass metabolism and incomplete absorption.Relationship to plasma proteins is low trenbolone enanthate 200. Sumatriptan is metabolized by the action of monoamine oxidase A main metabolite – indoleacetic analog output of sumatriptan, preferably in the urine in the form of free acid and glucuronide conjugate. This metabolite has no activity against serotonin receptors. Migraine attacks, apparently no significant effect on the pharmacokinetics of sumatriptan ingestable.
Relief of migraine attacks with or without aura.
- Hypersensitivity to any component of the formulation.
- Hemiplegic, basilar migraine and oftalmoplegicheskaya form.
- Coronary heart disease (including myocardial infarction, myocardial infarction, angina, Prinzmetal), as well as the presence of symptoms to trenbolone enanthate 200 suggest the presence of coronary artery disease.
- Occlusive peripheral vascular disease.
- Stroke or transient ischemic attack (including history).
- Uncontrolled hypertension.
- Receiving simultaneously with ergotamine or derivatives thereof (including methysergide).
- The use in patients receiving monoamine oxidase inhibitors or earlier than 2 weeks after the cancellation of these drugs.
- Severe liver and / or kidneys.
- Age 18 years and older than 65 years (safety and efficacy not established Sumiga).
- Pregnancy and lactation.Carefully:
- controlled hypertension.
- diseases that may change the absorption, metabolism or excretion of the drug (eg, renal or hepatic function).
- epilepsy (including any state with a reduction in seizure threshold).
- in patients with hypersensitivity to sulfonamides (administration sumatriptan can cause allergic reactions, the severity of which varies from cutaneous trenbolone enanthate 200 manifestations of anaphylaxis. Data on the cross-sensitivity is limited, however, caution should be exercised in the appointment of sumatriptan in these patients).
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