Following oral bioavailability of 37%, the maximum blood concentration established . Binding to plasma proteins is inversely proportional to the concentration in the blood and is 12-52%. It penetrates through the cell membrane (effective for infections caused by intracellular pathogens). Transported by phagocytes, polymorphonuclear leukocytes and macrophages to the site of infection, which is released in the presence of bacteria. Gistogematicalkie easily passes through the barriers and into the tissue. Concentration in tissues and cells 50 times higher than in blood plasma, and the source of infection – by 24-34% higher than in healthy tissues. Slowly derived from tissues and has a long half-life of 2-4 days. Therapeutic concentrations of azithromycin remains until 5-7 days after the last dose. Azithromycin is substantially unaltered – 50% intestines, kidneys 12%. The liver demethylated losing activity. In patients with renal failure side effects of trenbolone enanthate, the half-life of azithromycin is increased by 33%.
The infectious-inflammatory diseases caused by microorganisms sensitive to azithromycin:
- Upper respiratory tract infection and upper respiratory tract (pharyngitis, tonsillitis, sinusitis, otitis media);
- Lower respiratory tract infections (acute bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia, including those caused by atypical pathogens);
- Skin and soft tissue infections (common acne of moderate severity, erysipelas, impetigo, secondarily infected dermatitis);
- The initial stage of Lyme disease (borreliosis) – erythema migrans (erythema migrans);
- Uncomplicated urinary tract infections caused by Chlamidia trachomatis (urethritis, cervicitis).
Hypersensitivity to azithromycin, to other macrolide drug components, with the simultaneous use of ergot derivatives, severe hepatic / renal insufficiency, children under 12 years.
Long side effects of trenbolone enanthate, chronic renal insufficiency (creatinine clearance 40 mL / min), simultaneous with terfenadine, warfarin, digoxin, drugs that prolong the interval.
Pregnancy and lactation
Use of the drug during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus. If necessary, use during lactation should decide the issue of termination of breastfeeding.
Dosing and Administration
Inside, 1 time a day, at least 1 hour before or 2 hours after a meal.
Adults (including the elderly) and children over 12 years weighing more than 45 kg.
When infections of the upper and lower respiratory tract, upper respiratory tract, skin and soft tissues:
500 mg (1 tablet) 1 time per day for 3 days (course dose 1.5 g)
The initial stage of Lyme disease:
1 times per day for 5 days: 1 th day – 1.0 g (2 tablets), followed by the 2nd to 5th day – 500 mg (1 tablet) (course dose 3.0 g)
In uncomplicated urinary tract infections caused by Chlamidia trachomatis (urethritis, cervicitis ):
1 g (2 tablets) once.
course dose is 6 g: 500 mg (1 tablet) 1 time per day for 3 days, then 500 mg 1 time per week for 9 weeks.
Assignment patients with impaired renal function:
For patients with moderate renal side effects of trenbolone enanthate impairment (creatinine clearance> 40 ml / min) dose adjustment is not necessary. ripbol