Azithromycin – bakteriostatichёsky broad-spectrum antibiotic from macrolide-azalide. It has a wide spectrum of antimicrobial action. The mechanism of action of azithromycin is associated with the suppression of the microbial cell protein synthesis. By binding to the trenbolone enanthate resultsof the ribosome inhibits translation peptidtranslokazu on stage and inhibits protein synthesis, slowing the growth and reproduction of bacteria.In high concentrations it has a bactericidal effect. It has activity against a number of Gram-positive, Gram-negative, anaerobic, and other intracellular microorganisms. Microorganisms can initially be resistant to the antibiotic, or may acquire resistance to it. In most cases, the sensitive microorganism
- Gram-positive aerobes Staphylococcus aureus Methicillin-sensitive; of Streptococcus pneumoniae Penicillin-sensitive; of Streptococcus pyogenes .
- Gram-negative aerobic of Haemophilus influenzae; of Haemophilus parainfluenzae; of Legionella pneumophila; of Moraxella catarrhalis; of Pasteurella multocida; of Neisseria gonorrhoeae.
- Anaerobes of Clostridium perfringens; by Fusobacterium spp .; Prevotella spp .; Porphyriomonas spp.
- Other microorganisms Chlamydia trachomatis; Chlamydia pneumoniae; Chlamydia psittacv; Mycoplasma pneumoniae; Mycoplasma hominis; Borrelia burgdorferi.
Organisms capable of developing resistance to azithromycin Gram-positive aerobes Streptococcus pneumoniae trenbolone enanthate results.
Initially resistant organisms Gram-positive aerobes of Enterococcus faecalis ; Staphylococci (methicillin-resistant staphylococci exhibit a very high degree of resistance to macrolides), Gram-positive bacteria resistant to erythromycin.
Azithromycin is rapidly absorbed from the gastrointestinal tract due to its stability in an acidic medium and lipophilicity. It is rapidly distributed throughout the body in tissues with high concentrations of antibiotic achieved. After oral administration of 500 mg of azithromycin in the maximum concentration achieved in the plasma and 2.5-2.9 hours is 0.4 mg / l. Bioavailability is 37.5%.
Azithromycin well into the respiratory tract, organs and tissues of the urogenital tract (including the prostate), the skin and soft tissue. The high concentration in tissues (10-50 times higher than in blood plasma) and a long half-life of azithromycin due to low binding to plasma proteins, and its ability to penetrate into eukaryotic cells and concentrated in a lowtrenbolone enanthate resultsenvironment, environmental lysosomes. This, in turn, defines a large apparent volume of distribution (31.1 l / kg) and high plasma clearance. The ability of azithromycin to accumulate mainly in lysosomes is particularly important to eliminate intracellular pathogens. It proved that phagocytes deliver azithromycin localization of infection sites where it is released in the process of phagocytosis. The concentration of azithromycin in the foci of infection was significantly higher than in healthy tissue (on average 24-34%) and correlated with the degree of inflammatory edema. Azithromycin remains in bactericidal concentrations within 5-7 days after the last dose, which allowed the development of short (3 day and 5 day) treatments.
Demethylated in the liver, are not active metabolites formed. Excretion of azithromycin from plasma passes in 2 stages: half-life of 14-20 hours in the range of 8 to 24 hours after dosing, and 41 h – in the range from 24 to 72 hours to allow the use preparation 1 time / day.
Deduced drug mainly in the bile unchanged, a small portion excreted by the kidneys.